Acetaminophen Induces DNA Damage and ATM Mediated DNA Damage Repair in Mouse Hepatocytes

Brc1-mediated DNA repair and damage tolerance.

The structural maintenance of chromosome (SMC) proteins are key elements in controlling chromosome dynamics. In eukaryotic cells, three essential SMC complexes have been defined: cohesin, condensin, and the Smc5/6 complex. The latter is essential for DNA damage responses; in its absence both repair and checkpoint responses fail. In fission yeast, the UV-C and ionizing radiation (IR) sensitivity...

OGG1 DNA Repair Gene Polymorphism As a Biomarker of Oxidative and Genotoxic DNA Damage

Background: Single nucleotide polymorphisms in 8-oxoguanine DNA glycosylase-1 (OGG1) gene modulates DNA repair capacity and functions as one of the first lines of protective mechanisms against 8-hydroxy-2’-deoxyguanosine (8-OHdG) mutagenicity. OGG1-Cys326 gene polymorphism may decrease DNA repair function, causing oxidative stress due to higher oxidative DNA damage. The main purpose of this stu...

Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK

DNA double-strand breaks (DSB) are considered as the most deleterious DNA lesions, and their repair is further complicated by increasing damage complexity. However, the molecular effects of clustered lesions are yet not fully understood. As the locally restricted phosphorylation of H2AX to form γH2AX is a key step in facilitating efficient DSB repair, we investigated this process after localize...

Radiation track and DNA damage

Repair of topoisomerase I-mediated DNA damage.

Yves Pommier*, Juana Barcelo, V. Ashutosh Rao, Olivier Sordet, Andrew G. Jobson, Laurent Thibaut, Zheyong Miao, Jennifer Seiler, Hongliang Zhang, Christophe Marchand, Keli Agama and Christophe Redon Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, DHHS * To whom reprint requests should be addressed, Bldg. 37, Rm. 5068, N...